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Getting pregnant with clomiphene?

After several failed attempts to get pregnant, many couples involuntarily grapple with medical support options. For some people with an (unfulfilled) desire to have children, treatment with the drug clomiphene can be of help.

The tablet stimulates the pituitary gland and the diencephalon to produce hormones and thus triggers ovulation. In the article we tell you when to use the tablet and what effect or side effects it has.

Overview:

When should one use clomiphene?

Treatment with clomiphene (also clomiphene) when trying to have children is particularly useful if the woman has problems with ovulation and / or follicle maturation. It is also possible that ovulation does not take place at all and can only be stimulated with medical support. Pregnancy only occurs if sexual intercourse is carried out in the cycle shortly before ovulation - i.e. on the fertile days.

The majority of women start taking the drug clomiphene in consultation with their doctor after about a year with an unfulfilled desire to have children and a lack of ovulation or impaired follicular maturation.

Before taking it, pregnancy must be ruled out by means of a pregnancy test, as otherwise the preparation could have a negative impact on the embryo.

How does clomiphene work?

The aim of treatment with the anti-estrogen clomiphene is to stimulate the pituitary gland. This releases the two hormones LH - the luteinizing hormone - and FSH - the follicle-stimulating hormone - the production of which is essential for the desire to have children. The hormone FSH stimulates the female follicles to mature and the male to produce sperm. LH promotes ovulation and the formation of corpuscles.

Clomiphene weakens the negative feedback from the body's own estrogens. This leads to the release of GnRH (gonadotropin-releasing hormone) in the diencephalon (hypothalamus). FSH (follicle-stimulating hormone) and LH (luteinizing hormone) are then released in the pituitary gland. FSH and LH stimulate follicle maturation and trigger ovulation.


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The effect of clomiphene occurs quickly after the first intake and thus regulates the female cycle. Normally, the egg cell jumps around the 14th day of the cycle.

Researching the Internet often reveals articles about the use of clomiphene in male infertility. The data situation is still partly contradicting. However, recent research suggests that some men could benefit from therapy. This is an "off-label" use, which means that the drug is actually not approved for use in men. Whether a therapy makes sense should therefore be discussed with the treating urologist / andrologist on a case-by-case basis.

How should one take clomiphene?

Clomiphene is given in tablet form. The exact dosage of the hormone treatment is determined by the attending physician. A different dosage may have negative consequences. The drug requires a prescription and should only be taken under medical supervision.

What are the side effects of taking it?

As with many medications, taking clomiphene can cause side effects in women. Therefore, a doctor should always accompany and monitor the treatment and clomiphene intake. The most common side effects include nausea, gastrointestinal disorders and headaches, visual disturbances and hot flashes. Occasionally, it can lead to depressive moods.

Clomiphene can adversely affect the lining of the uterus by blocking estrogen receptors, which can make pregnancy difficult. Should this occur, clomiphene therapy must be reconsidered.

It can also lead to ovarian enlargement and even hyperstimulation.

If some symptoms seem excessive to you, you should contact your doctor and have other causes clarified.

After the egg has been fertilized, there are no known cases in which the use of clomiphene citrate in the subsequent pregnancy resulted in negative consequences. The risk of multiple pregnancies is increased with clomiphene, therefore, as already mentioned, therapy should only be carried out under medical supervision.

 

Swell:

https://www.pharmawiki.ch/wiki/index.php?wiki=Clomifen
https://www.ncbi.nlm.nih.gov/pubmed/23202725
https://www.allgemeinarzt-online.de/archiv/a/kinderwunsch-erfuellbar-1813267

 

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