What does gating mean

Electrophysiology pp 93-118 | Cite as

  • Jürgen Rettinger
  • Silvia Schwarz
  • Wolfgang Schwarz
First Online:


In chap. 5 we discussed the selectivity of ion channels and the ion permeation process in detail. Another important property of pores is the kinetics of their opening and closing, their gating behavior. We had already addressed this property when we discussed the characterization of individual channels using the patch-clamp technique and the analysis of current fluctuations and gating currents. The patch-clamp technique in particular has expanded the understanding of electrophysiological phenomena to include a new “microscopic” dimension. In the following we want to consider a phenomenon called excitability, the elucidation of which, although on a macroscopic level, represented a milestone in electrophysiology. In this context, macroscopic means that a large number of simultaneous single channel events contribute to the measured signal.

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© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Jürgen Rettinger
  • Silvia Schwarz
  • Wolfgang Schwarz
  1. 1. Multi Channel Systems MCS GmbHReutlingenGermany
  2. 2.Shanghai Key Laboratory for Acupuncture Mechanism and Acupoint FunctionFudan UniversityShanghaiChina
  3. 3.Shanghai Research Center for Acupuncture and MeridiansShanghai University of Traditional Chinese MedicineShanghaiChina
  4. 4.Institute for BiophysicsGoethe University FrankfurtFrankfurt am MainGermany